Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

4,6-Dichloroindole-2-carboxylic acid

  • CAS No. 101861-63-6

  • Cat. No. CS-W022054
  • Purity≥97%
  • MDL No.MFCD00209870

*For research and further manufacturing use only, not for direct human use.

4,6-Dichloroindole-2-carboxylic acid|CS-W022054

Structure of 101861-63-6

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 101861-63-6
  • Cat. No. CS-W022054
  • Purity ≥97%
  • MDL No. MFCD00209870
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₅Cl₂NO₂
  • Molecular Weight 230.05
  • Synonym(s) 4,6-dichloro-1H-indole-2-carboxylic acid
  • SMILES O=C(C(N1)=CC2=C1C=C(Cl)C=C2Cl)O

Description

4,6-Dichloroindole-2-carboxylic acid features a rigid indole core with two chlorine atoms at the 4 and 6 positions, enhancing electron-withdrawal and metabolic stability. The carboxylic acid group enables direct coupling or derivatization in synthetic routes. This compound serves as a key building block for bioactive heterocycles, particularly in medicinal chemistry applications where halogenated scaffolds improve target binding affinity and pharmacokinetic properties.

Application

4,6-Dichloroindole-2-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of indole-based heterocycles through standard coupling and functionalization protocols. Its dual chloro substituents enhance electrophilicity at C4 and C6, facilitating palladium-catalyzed cross-couplings and nucleophilic aromatic substitution reactions. The carboxylic acid group provides a handle for amide formation, esterification, or salt generation, supporting purification and derivatization. Bench-stable and readily handled, it functions effectively in multi-step syntheses targeting API scaffolds and kinase inhibitors.

Synthesis

  • Route1

    References

    • NOVARTIS AG; JIRICEK, Jan; KONDREDDI, Ravinder Reddy; SMITH, Paul William Patent: WO2014/37900 A1, 2014 ; Location in patent: Paragraph 27; 28 ;
  • Route2
    • null|null
      626-43-7
    • ~%
    • In-stock
      4,6-Dichloroindole-2-carboxylic acid|CS-W022054
      101861-63-6

    References

    • WO2014/37900 A1, ;
  • Route3
    • (3,5-Dichlorophenyl)hydrazine|CS-W017383
      39943-56-1
    • ~%
    • In-stock
      4,6-Dichloroindole-2-carboxylic acid|CS-W022054
      101861-63-6

    References

    • WO2014/37900 A1, ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   53.09
  • LogP   3.1729
  • H_Acceptors   1
  • H_Donors   2
  • Rotatable_Bonds   1

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 4,6-Dichloroindole-2-carboxylic acid sigma4,6-Dichloroindole-2-carboxylic acid manufacturer4,6-Dichloroindole-2-carboxylic acid price4,6-Dichloroindole-2-carboxylic acid structure4,6-Dichloroindole-2-carboxylic acid SDSbuy 4,6-Dichloroindole-2-carboxylic acid4,6-Dichloroindole-2-carboxylic acid supplier4,6-Dichloroindole-2-carboxylic acid uses4,6-Dichloroindole-2-carboxylic acid molecular weightprice of 4,6-Dichloroindole-2-carboxylic acid4,6-Dichloroindole-2-carboxylic acid chemical name formula of 4,6-Dichloroindole-2-carboxylic acid
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label