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CS-W001157 4
Total: USD 88.00

3-(Trifluoromethyl)picolinic acid

  • CAS No. 87407-12-3

  • Cat. No. CS-W003406
  • Purity≥98%
  • MDL No.MFCD07375386

*For research and further manufacturing use only, not for direct human use.

3-(Trifluoromethyl)picolinic acid|CS-W003406

Structure of 87407-12-3

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General Information

  • CAS No. 87407-12-3
  • Cat. No. CS-W003406
  • Purity ≥98%
  • MDL No. MFCD07375386
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₄F₃NO₂
  • Molecular Weight 191.11
  • Synonym(s) 3-(Trifluoromethyl)pyridine-2-carboxylic Acid
  • SMILES OC(=O)c1ncccc1C(F)(F)F

Description

3-(Trifluoromethyl)picolinic acid features a trifluoromethyl group at the 3-position of the picolinic acid scaffold, delivering enhanced electron-withdrawing character and improved metabolic stability. This structural motif enables robust coupling in peptide synthesis and facilitates integration into bioactive molecules requiring high lipophilicity and resistance to oxidative degradation.

Application

3-(Trifluoromethyl)picolinic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its trifluoromethyl group imparts enhanced metabolic stability and lipophilicity, while the pyridine carboxylic acid core facilitates diverse transformations including amidation, esterification, and coupling reactions. The compound exhibits good bench stability and is compatible with standard synthetic workflows.

Synthesis

  • Route1
    • null|null
      3796-23-4
    • null|null
      124-38-9
    • ~76%
    • In-stock
      3-(Trifluoromethyl)picolinic acid|CS-W003406
      87407-12-3

    References

    • Porwisiak, Jacek; Dmowski, Wojciech Tetrahedron, 1994 , vol. 50, # 42 p. 12259 - 12266
  • Route2
    • null|null
      124-38-9
    • In-stock
      2-Bromo-3-(trifluoromethyl)pyridine|CS-W013033
      175205-82-0
    • ~66%
    • In-stock
      3-(Trifluoromethyl)picolinic acid|CS-W003406
      87407-12-3

    References

    • Cottet, Fabrice; Marull, Marc; Lefebvre, Olivier; Schlosser, Manfred European Journal of Organic Chemistry, 2003 , # 8 p. 1559 - 1568
  • Route3

    References

    • European Journal of Organic Chemistry, , # 8 p. 1559 - 1568

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   1.7986
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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