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CS-W001157 4
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2-Bromo-6,7-dihydrothieno[3,2-c]pyridin-4(5H)-one

  • CAS No. 1078150-17-0

  • Cat. No. CS-W006272
  • Purity≥95%
  • MDL No.MFCD11656583

*For research and further manufacturing use only, not for direct human use.

2-Bromo-6,7-dihydrothieno[3,2-c]pyridin-4(5H)-one|CS-W006272

Structure of 1078150-17-0

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General Information

  • CAS No. 1078150-17-0
  • Cat. No. CS-W006272
  • Purity ≥95%
  • MDL No. MFCD11656583
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆BrNOS
  • Molecular Weight 232.10
  • Synonym(s) 2-bromo-4H,5H,6H,7H-thieno[3,2-c]pyridin-4-one
  • SMILES O=C1C(C=C(Br)S2)=C2CCN1

Description

2-Bromo-6,7-dihydrothieno[3,2-c]pyridin-4(5H)-one features a fused thienopyridinone core with a bromine substituent at the 2-position, enabling direct functionalization in cross-coupling reactions. The saturated thiophene ring enhances solubility and stability under standard conditions, while the carbonyl group provides a key handle for derivatization. This scaffold serves as a privileged building block in medicinal chemistry.

Application

2-Bromo-6,7-dihydrothieno[3,2-c]pyridin-4(5H)-one serves as a versatile heterocyclic building block for medicinal chemistry and synthetic organic applications. The bromine substituent enables palladium-catalyzed cross-coupling reactions, while the lactam functionality provides structural rigidity and hydrogen-bonding capability. This scaffold exhibits good bench stability and compatibility with common protecting group strategies, facilitating efficient access to complex polycyclic systems through modular synthesis.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   29.1
  • LogP   1.7965
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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