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CS-W001157 4
Total: USD 88.00

4-Bromo-3-chloro-2-fluoropyridine

  • CAS No. 1017793-21-3

  • Cat. No. CS-0046223
  • Purity≥96%
  • MDL No.MFCD11040607
  • HazMat Fee +

    HazMat Fee

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

4-Bromo-3-chloro-2-fluoropyridine|CS-0046223

Structure of 1017793-21-3

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Description

4-Bromo-3-chloro-2-fluoropyridine is a halogenated pyridine derivative featuring strategically positioned bromo, chloro, and fluoro substituents. This electron-deficient heterocycle enables direct functionalization in cross-coupling reactions and serves as a key scaffold for medicinal chemistry libraries. The orthogonal reactivity of its halogens permits sequential derivatization under mild conditions.

Application

4-Bromo-3-chloro-2-fluoropyridine serves as a versatile trifunctional pyridine building block for medicinal chemistry and catalytic cross-coupling applications. Its orthogonal halogen reactivity enables sequential functionalization via Pd-catalyzed coupling, while the electron-deficient pyridine core enhances stability and facilitates nucleophilic substitution. Bench-stable and amenable to purification by distillation or flash chromatography, it functions reliably in the construction of complex heterocyclic scaffolds and API intermediates.

General Information

  • CAS No. 1017793-21-3
  • Cat. No. CS-0046223
  • Purity ≥96%
  • MDL No. MFCD11040607
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₂BrClFN
  • Molecular Weight 210.43
  • Synonym(s) 4-BROMO-3-CHLORO-2-FLUORO-PYRIDINE
  • SMILES FC1=NC=CC(Br)=C1Cl

Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.6366
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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