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CS-W001157 4
Total: USD 88.00

4-Methoxynicotinic acid

  • CAS No. 10177-31-8

  • Cat. No. CS-0082368
  • Purity≥97%
  • MDL No.MFCD04115724
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

4-Methoxynicotinic acid|CS-0082368

Structure of 10177-31-8

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Description

4-Methoxynicotinic acid is a bench-stable, moisture-tolerant pyridine carboxylic acid featuring a para-methoxy substituent that enhances solubility and modulates electronic properties. This derivative serves as a key scaffold in medicinal chemistry for constructing bioactive heterocycles and functional polymers, integrating readily into coupling reactions under standard conditions.

Application

4-Methoxynicotinic acid serves as a versatile building block in medicinal chemistry and synthetic organic chemistry, enabling efficient access to bioactive heterocycles and pharmaceutical intermediates. Its electron-rich pyridine core and orthogonal functional groups facilitate diverse transformations, including amidation, esterification, and coupling reactions. The methoxy substituent enhances solubility and modulates electronic properties, while the carboxylic acid group offers direct handle for derivatization. Bench-stable and readily purified, it functions reliably in standard synthetic workflows.

General Information

  • CAS No. 10177-31-8
  • Cat. No. CS-0082368
  • Purity ≥97%
  • MDL No. MFCD04115724
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇NO₃
  • Molecular Weight 153.14
  • Synonym(s) 4-METHOXY-3-PYRIDINECARBOXYLIC ACID
  • SMILES COC1=C(C(O)=O)C=NC=C1

Computational Chemistry Data

  • TPSA   59.42
  • LogP   0.7884
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H319
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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