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Structure of 1007587-63-4
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This trimethylsilyl-protected alkyne-bearing phenylmethanol features a reactive terminal alkyne flanked by a hydroxymethyl group, enabling seamless incorporation into Sonogashira couplings and subsequent desilylation. The silyl ether moiety confers enhanced stability and solubility in organic media, simplifying handling and purification under standard conditions.
(3-((Trimethylsilyl)ethynyl)phenyl)methanol serves as a versatile building block in synthetic organic chemistry, enabling efficient access to functionalized aryl alkynes. The trimethylsilyl group provides excellent stability and orthogonality, facilitating selective deprotection and downstream coupling reactions. Its terminal alkyne functionality readily participates in copper-catalyzed azide-alkyne cycloadditions (CuAAC), while the pendant alcohol allows for derivatization or protection. This compound exhibits good bench stability, ease of purification, and compatibility with standard reaction conditions, making it well-suited for medicinal chemistry and materials synthesis workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319
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Precautionary Statements : P264-P280-P302+P352-P362
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Lot numbers can be found on the outside label of a product: