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CS-W001157 4
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(4-((Trimethylsilyl)ethynyl)phenyl)methanol

  • CAS No. 275386-60-2

  • Cat. No. CS-0158146
  • Molecule weight204.34
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(4-((Trimethylsilyl)ethynyl)phenyl)methanol|CS-0158146

Structure of 275386-60-2

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General Information

  • CAS No. 275386-60-2
  • Cat. No. CS-0158146
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₆OSi
  • Molecular Weight 204.34
  • Synonym(s) Benzenemethanol, 4-[2-(trimethylsilyl)ethynyl]-
  • SMILES C[Si](C)(C)C#CC1=CC=C(C=C1)CO

Description

This boronate moiety integrates a trimethylsilyl-protected alkyne with a pendant hydroxyl group, enabling orthogonal functionalization in complex synthesis. The silyl-protected alkyne resists moisture and air, while the benzylic alcohol facilitates downstream derivatization under mild conditions.

Application

(4-((Trimethylsilyl)ethynyl)phenyl)methanol serves as a versatile building block in synthetic organic chemistry, enabling efficient access to substituted phenylacetylenes via mild desilylation. The trimethylsilyl group provides excellent stability and compatibility with diverse reaction conditions, while the terminal alkyne functionality facilitates copper-catalyzed coupling reactions. Its benzylic alcohol moiety allows for selective derivatization or protection, supporting orthogonal functionalization strategies. This compound is particularly valuable in constructing complex scaffolds for medicinal chemistry and materials science applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   2.4078
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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