1-(2,2-Difluoroethyl)-1H-pyrazol-4-amine

Name: 1-(2,2-Difluoroethyl)-1H-pyrazol-4-amine
Brand: ChemScene
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CAS No. 1006333-08-9
Cat. No. CS-0155483
Purity≥95%
MDL No.None

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1-(2,2-Difluoroethyl)-1H-pyrazol-4-amine|CS-0155483

Structure of 1006333-08-9

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General Information

CAS No. 1006333-08-9
Cat. No. CS-0155483
Purity ≥95%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₇F₂N₃
Molecular Weight 147.13
Synonym(s) 1-(2,2-DIFLUOROETHYL)PYRAZOL-4-AMINE
SMILES C1=NN(C=C1N)CC(F)F

Description

1-(2,2-Difluoroethyl)-1H-pyrazol-4-amine features a pyrazole core bearing a primary amine at C4 and a difluoroethyl substituent at N1. This electron-deficient scaffold integrates readily into medicinal chemistry campaigns, offering enhanced metabolic stability and improved membrane permeability due to the fluorinated side chain.

Application

1-(2,2-Difluoroethyl)-1H-pyrazol-4-amine serves as a versatile building block in medicinal chemistry, enabling the construction of fluorinated heterocyclic scaffolds. The difluoroethyl side chain enhances metabolic stability and modulates lipophilicity, while the pyrazole amine moiety facilitates coupling reactions and hydrogen bonding interactions. Its bench-stable nature and compatibility with standard synthetic protocols make it well-suited for iterative library synthesis and API development.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

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Computational Chemistry Data

TPSA 43.84
LogP 0.7304
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 2

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aromatic heterocycle compounds Pyrazole compounds

Key Words

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1-(2,2-Difluoroethyl)-1H-pyrazol-4-amine

CAS No. 1006333-08-9

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