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CS-W001157 4
Total: USD 88.00

2-Phenylthiazole-5-carboxylic acid

  • CAS No. 10058-38-5

  • Cat. No. CS-W006497
  • Purity≥98%
  • MDL No.MFCD07376773

*For research and further manufacturing use only, not for direct human use.

2-Phenylthiazole-5-carboxylic acid|CS-W006497

Structure of 10058-38-5

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General Information

  • CAS No. 10058-38-5
  • Cat. No. CS-W006497
  • Purity ≥98%
  • MDL No. MFCD07376773
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₇NO₂S
  • Molecular Weight 205.23
  • Synonym(s) 2-PHENYL-THIAZOLE-5-CARBOXYLIC ACID
  • SMILES O=C(C1=CN=C(C2=CC=CC=C2)S1)O

Description

2-Phenylthiazole-5-carboxylic acid features a rigid heteroaromatic core that enhances π-stacking interactions in supramolecular assemblies. The carboxylic acid group enables direct conjugation with amine-functionalized scaffolds, while the phenyl substituent provides steric and electronic modulation. This compound serves as a key building block for bioactive thiazole derivatives and functional materials.

Application

2-Phenylthiazole-5-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling efficient construction of thiazole-based heterocycles. Its carboxylic acid functionality facilitates direct coupling reactions and derivatization, while the phenyl-substituted thiazole core offers enhanced metabolic stability and π–π stacking potential. The compound exhibits good bench stability and is compatible with standard purification protocols, making it well-suited for use in high-throughput synthesis and API intermediate development.

Synthesis

  • Route1
    • Ethyl 2-phenylthiazole-5-carboxylate|CS-0151703
      172678-67-0
    • ~%
    • In-stock
      2-Phenylthiazole-5-carboxylic acid|CS-W006497
      10058-38-5

    References

    • Wang, Liang; Dai, Fu-Ying; Zhu, Jie; Dong, Kui-Kui; Wang, Yu-Liang; Chen, Tian Journal of Chemical Research, 2011 , vol. 35, # 5 p. 313 - 316
  • Route2

    References

    • Silberg,A. et al. Chemische Berichte, 1964 , vol. 97, p. 1684 - 1687
  • Route3

    References

    • Wang, Liang; Dai, Fu-Ying; Zhu, Jie; Dong, Kui-Kui; Wang, Yu-Liang; Chen, Tian Journal of Chemical Research, 2011 , vol. 35, # 5 p. 313 - 316

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   2.5083
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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