Lot numbers can be found on the outside label of a product:
6-Amino-3,3-dimethylindolin-2-one
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CAS No. 100510-65-4
- Cat. No. CS-W003764
- Purity≥98%
- MDL No.MFCD11053509
*For research and further manufacturing use only, not for direct human use.
Structure of 100510-65-4
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General Information
- CAS No. 100510-65-4
- Cat. No. CS-W003764
- Purity ≥98%
- MDL No. MFCD11053509
- Storage 4°C, protect from light
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₀H₁₂N₂O
- Molecular Weight 176.22
- Synonym(s) AP3Impurity6
- SMILES O=C1NC2=C(C=CC(N)=C2)C1(C)C
Description
6-Amino-3,3-dimethylindolin-2-one features a sterically hindered indolinone core with a primary amine at the 6-position, enabling direct functionalization in peptide and heterocyclic synthesis. The electron-rich amine pairs effectively with the carbonyl group, facilitating nucleophilic additions and conjugate reactions under mild conditions. This bench-stable compound serves as a key scaffold for bioactive molecule development.
Application
6-Amino-3,3-dimethylindolin-2-one serves as a versatile building block in medicinal chemistry, enabling efficient access to indoline-based scaffolds prevalent in bioactive molecules. Its amino group facilitates direct functionalization or coupling reactions, while the dimethyl-substituted ring enhances metabolic stability and modulates solubility. The compound exhibits excellent bench stability and compatibility with standard synthetic transformations, making it well-suited for modular synthesis of kinase inhibitors and CNS-targeted therapeutics.
Synthesis
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Route1
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In-stock
100510-64-3 - ~%
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In-stock
100510-65-4
References
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US2006/258689 A1, ; Page/Page column 35 ;
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Route2
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1256633-16-5 - ~65%
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In-stock
100510-65-4
References
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Li, Yanyang; Shi, Xiangfei; Xie, Ning; Zhao, Yanjin; Li, Shuxin MedChemComm, 2013 , vol. 4, # 2 p. 367 - 370
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Route3
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In-stock
2901-13-5 - ~%
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In-stock
100510-65-4
References
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MedChemComm, , vol. 4, # 2 p. 367 - 370
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H319
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 55.12
- LogP 1.4985
- H_Acceptors 2
- H_Donors 2
- Rotatable_Bonds 0
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Key Words
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