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CS-W001157 4
Total: USD 88.00

5-Fluoro-2-methoxypyridin-3-amine

  • CAS No. 1211541-93-3

  • Cat. No. CS-W022380
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-Fluoro-2-methoxypyridin-3-amine|CS-W022380

Structure of 1211541-93-3

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General Information

  • CAS No. 1211541-93-3
  • Cat. No. CS-W022380
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₇FN₂O
  • Molecular Weight 142.13
  • Synonym(s) 5-Fluoro-2-Methoxy-pyridin-3-ylaMine
  • SMILES COC1=NC=C(F)C=C1N

Description

5-Fluoro-2-methoxypyridin-3-amine features a pyridine core with strategically positioned fluorine and methoxy groups, enabling enhanced electron-withdrawing effects and improved metabolic stability. This bench-stable compound integrates readily into medicinal chemistry scaffolds, serving as a key building block for kinase inhibitors and bioactive heterocycles.

Application

5-Fluoro-2-methoxypyridin-3-amine serves as a versatile building block in medicinal chemistry, enabling efficient access to pyridine-based pharmacophores. The ortho-fluoro and amino groups facilitate directed metalation and palladium-catalyzed coupling reactions, while the methoxy substituent enhances solubility and modulates electronic properties. Bench-stable and compatible with standard synthetic protocols, it functions effectively in the construction of kinase inhibitors and CNS-targeted compounds.

Synthesis

  • Route1
    • 5-Fluoro-2-methoxy-3-nitropyridine|CS-0088285
      1211534-27-8
    • ~86%
    • In-stock
      5-Fluoro-2-methoxypyridin-3-amine|CS-W022380
      1211541-93-3

    References

    • EP2527344 A1, ; Page/Page column 22-23 ; EP 2527344 A1
  • Route2

    References

    • EP2527344 A1, ; EP 2527344 A1
  • Route3

    References

    • EP2527344 A1, ; EP 2527344 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   48.14
  • LogP   0.8115
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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