Lot numbers can be found on the outside label of a product:
1,3-Dihydro-3,3-dimethyl-2H-indol-2-one
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CAS No. 19155-24-9
- Cat. No. CS-W009190
- Purity≥96%
- MDL No.MFCD00158549
*For research and further manufacturing use only, not for direct human use.
Structure of 19155-24-9
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General Information
- CAS No. 19155-24-9
- Cat. No. CS-W009190
- Purity ≥96%
- MDL No. MFCD00158549
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₀H₁₁NO
- Molecular Weight 161.20
- Synonym(s) Oxindole, 3,3-dimethyl-; 3,3-Dimethylindolin-2-one
- SMILES O=C1NC2=C(C=CC=C2)C1(C)C
Description
This indolone scaffold features a sterically shielded, bench-stable core with enhanced solubility in polar organic solvents. The 3,3-dimethyl substitution prevents undesired side reactions at the C3 position, while the lactam functionality enables direct incorporation into bioactive molecule frameworks.
Application
1,3-Dihydro-3,3-dimethyl-2H-indol-2-one serves as a stable, bench-ready building block for indole-based scaffolds. Its dimethyl-substituted C3 position enhances regiochemical control in electrophilic substitutions and facilitates functionalization at C2. The ketone moiety enables direct use in reductive amination, nucleophilic addition, and transition-metal-catalyzed coupling reactions. This compound functions effectively in the synthesis of heterocyclic intermediates and biologically relevant frameworks with predictable reactivity and straightforward purification.
Synthesis
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Route1
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157984-41-3 - ~38%
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In-stock
19155-24-9
References
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Johnson, A. Peter; Dutton, Jonathan K.; Pleynet, David P. M. Heterocycles, 1994 , vol. 37, # 3 p. 1913 - 1932
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Route2
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![1H-Benzo[d][1,2,3]triazole Bortezomib Impurity|CS-0229225](https://file.chemscene.com/productPIC/CS-0229225.gif)
95-14-7 - ~%
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In-stock
19155-24-9
References
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Heterocycles, , vol. 37, # 3 p. 1913 - 1932
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Route3
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In-stock
![1-((Trimethylsilyl)methyl)-1H-benzo[d][1,2,3]triazole|CS-0088527](https://file.chemscene.com/productPIC/CS-0088527.gif)
122296-00-8 - ~%
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In-stock
19155-24-9
References
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Heterocycles, , vol. 37, # 3 p. 1913 - 1932
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 29.1
- LogP 1.9163
- H_Acceptors 1
- H_Donors 1
- Rotatable_Bonds 0
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Key Words
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