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N-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine

  • CAS No. 1005009-98-2

  • Cat. No. CS-0034160
  • Purity≥97%
  • MDL No.MFCD11878220

*For research and further manufacturing use only, not for direct human use.

N-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine|CS-0034160

Structure of 1005009-98-2

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General Information

  • CAS No. 1005009-98-2
  • Cat. No. CS-0034160
  • Purity ≥97%
  • MDL No. MFCD11878220
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₉BN₂O₂
  • Molecular Weight 234.10
  • Synonym(s) None
  • SMILES CC1(C)C(C)(C)OB(C2=CN=C(NC)C=C2)O1

Description

N-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine delivers a bench-stable boronate handle paired with a nitrogen-rich heterocyclic core. This compound integrates readily into Suzuki-Miyaura cross-coupling reactions, enabling efficient construction of biaryl scaffolds in medicinal chemistry and materials science applications.

Application

N-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine serves as a versatile boronate building block for Suzuki-Miyaura cross-coupling reactions. The pyridine nitrogen and methylated amine functionality provide enhanced solubility and stability, while the tetramethylboronate group enables efficient coupling under mild conditions. Its bench-stable nature and compatibility with diverse functional groups make it ideal for constructing biaryl scaffolds in medicinal chemistry and materials science applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   43.38
  • LogP   1.4225
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   2

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