tert-Butyl (5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)carbamate

Name: tert-Butyl (5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)carbamate
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 910462-31-6
Cat. No. CS-0046250
Purity≥97%
MDL No.None

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

tert-Butyl (5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)carbamate|CS-0046250

Structure of 910462-31-6

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 910462-31-6
Cat. No. CS-0046250
Purity ≥97%
MDL No. None
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₆H₂₅BN₂O₄
Molecular Weight 320.19
Synonym(s) tert-butyl [5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]carbamate
SMILES O=C(OC(C)(C)C)NC1=NC=C(B2OC(C)(C)C(C)(C)O2)C=C1

Description

tert-Butyl (5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)carbamate is a bench-stable boronate ester featuring a pyridine scaffold with a protected amine. This reagent enables efficient Suzuki-Miyaura coupling under mild conditions, combining high functional group tolerance with ease of handling. The tetramethyl-dioxaborolane moiety ensures stability and low toxicity, while the tert-butyl carbamate group provides orthogonal protection for nitrogen-based transformations.

Application

tert-Butyl (5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)carbamate serves as a stable, bench-ready boron building block for palladium-catalyzed cross-coupling reactions. The pyridine core enables versatile functionalization in medicinal chemistry and materials science, while the Bpin group facilitates efficient Suzuki-Miyaura coupling under mild conditions. The tert-butyl carbamate protects the amine selectively, offering orthogonal handling and ease of removal post-coupling. This reagent exhibits excellent functional group tolerance and reproducible yields in standard synthetic workflows.

Synthesis

Route1
- In-stock
  
  827614-64-2
- In-stock
  
  24424-99-5
- ~44%
- In-stock
  
  910462-31-6
References
- AMBIT BIOSCIENCES CORPORATION; ABRAHAM, Sunny; HOLLADAY, Mark, W.; LIU, Gang; XU, Shimin Patent: WO2011/22473 A1, 2011 ; Location in patent: Page/Page column 127 ; WO 2011/022473 A1
Route2
- In-stock
  
  73183-34-3
- In-stock
  
  159451-66-8
- ~%
- In-stock
  
  910462-31-6
References
- WO2006/97474 A1, ; Page/Page column 135 ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 69.68
LogP 2.7278
H_Acceptors 5
H_Donors 1
Rotatable_Bonds 2

Other Classifications

Building Blocks Functional Group Amine

Building Blocks Functional Group Boronic Acid And Its Ester

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

910462-31-6 sigma910462-31-6 manufacturer910462-31-6 price910462-31-6 structure910462-31-6 SDSbuy 910462-31-6910462-31-6 supplier910462-31-6 uses910462-31-6 molecular weightprice of 910462-31-6910462-31-6 chemical name formula of 910462-31-6

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

tert-Butyl (5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)carbamate

CAS No. 910462-31-6

Recommended Products