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CS-W001157 4
Total: USD 88.00

2,5-Dihydrofuran-3-carboxylic acid

  • CAS No. 1002728-73-5

  • Cat. No. CS-0370980
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2,5-Dihydrofuran-3-carboxylic acid|CS-0370980

Structure of 1002728-73-5

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General Information

  • CAS No. 1002728-73-5
  • Cat. No. CS-0370980
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₆O₃
  • Molecular Weight 114.10
  • Synonym(s) None
  • SMILES O=C(C1=CCOC1)O

Description

This 2,5-dihydrofuran-3-carboxylic acid features a reactive α,β-unsaturated carbonyl system within a stable five-membered heterocycle. The carboxylic acid group enables direct functionalization or salt formation, while the dihydrofuran scaffold offers moderate stability and compatibility with common organic solvents. This structure serves as a key intermediate in synthesizing bioactive molecules and functional polymers.

Application

2,5-Dihydrofuran-3-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling efficient access to bioactive heterocycles through established functional group transformations. Its conjugated enolizable carbonyl and unsaturated furan framework facilitate Diels–Alder reactions, metal-catalyzed couplings, and derivatization under mild conditions. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for iterative synthesis workflows and API intermediate development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

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Computational Chemistry Data

  • TPSA   46.53
  • LogP   0.0276
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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