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3-Bromo-4-hydroxybenzoic acid

  • CAS No. 14348-41-5

  • Cat. No. CS-0157135
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3-Bromo-4-hydroxybenzoic acid|CS-0157135

Structure of 14348-41-5

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General Information

  • CAS No. 14348-41-5
  • Cat. No. CS-0157135
  • Purity ≥98%
  • MDL No. None
  • Storage RT, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅BrO₃
  • Molecular Weight 217.02
  • Synonym(s) 3-bromo-4-hydroxybenzoate
  • SMILES C1=CC(=C(C=C1C(=O)O)Br)O

Description

3-Bromo-4-hydroxybenzoic acid features a bromine substituent at the meta position relative to the carboxylic acid, paired with a para-hydroxyl group, enabling dual functionalization in synthetic sequences. This combination delivers enhanced reactivity in cross-coupling and derivatization processes, particularly valuable in pharmaceutical and agrochemical intermediates. The molecule exhibits good solubility in common organic solvents and maintains stability under standard bench conditions.

Synthesis

  • Route1
    • 4-Hydroxybenzoic acid  Cetirizine Impurity|CS-0167040
      99-96-7
    • ~98%
    • In-stock
      3-Bromo-4-hydroxybenzoic acid|CS-0157135
      14348-41-5

    References

    • Mukhopadhyay, Sudip; Ananthakrishnan; Chandalia, Sampatraj B. Organic Process Research and Development, 1999 , vol. 3, # 6 p. 451 - 454
  • Route2

    References

    • Journal of Organic Chemistry, , vol. 50, # 7 p. 973 - 976
  • Route3
    • null|null
      106-44-5
    • ~%
    • In-stock
      3-Bromo-4-hydroxybenzoic acid|CS-0157135
      14348-41-5

    References

    • Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), , p. 32 - 41

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H318
Precautionary Statements : P264-P270-P280-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   57.53
  • LogP   1.8529
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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