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CS-W001157 4
Total: USD 88.00

4-Amino-6-chloronicotinaldehyde

  • CAS No. 1001756-21-3

  • Cat. No. CS-0038140
  • Purity≥95%
  • MDL No.MFCD09834660

*For research and further manufacturing use only, not for direct human use.

4-Amino-6-chloronicotinaldehyde|CS-0038140

Structure of 1001756-21-3

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General Information

  • CAS No. 1001756-21-3
  • Cat. No. CS-0038140
  • Purity ≥95%
  • MDL No. MFCD09834660
  • Storage -20°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅ClN₂O
  • Molecular Weight 156.57
  • Synonym(s) None
  • SMILES C1=C(C(=CN=C1Cl)C=O)N

Description

4-Amino-6-chloronicotinaldehyde features a strategically positioned aldehyde group flanked by electron-donating amino and electron-withdrawing chloro substituents, enabling selective coupling reactions in heterocyclic synthesis. This bench-stable scaffold integrates readily into bioactive molecule architectures requiring polar functionality and tailored electronic properties.

Application

4-Amino-6-chloronicotinaldehyde serves as a versatile building block in medicinal chemistry, enabling the synthesis of heterocyclic scaffolds via condensation and cyclization reactions. Its dual functional groups—aldehyde and amino—facilitate efficient derivatization under mild conditions, while the chlorine substituent supports further cross-coupling transformations. The compound exhibits good bench stability and is amenable to purification by chromatography or recrystallization, making it well-suited for iterative synthesis campaigns in API development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   55.98
  • LogP   1.1297
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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