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CS-W001157 4
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Sodium difluoromethanesulfinate

  • CAS No. 275818-95-6

  • Cat. No. CS-0121058
  • Purity≥95%
  • MDL No.MFCD24113355

*For research and further manufacturing use only, not for direct human use.

Sodium difluoromethanesulfinate|CS-0121058

Structure of 275818-95-6

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General Information

  • CAS No. 275818-95-6
  • Cat. No. CS-0121058
  • Purity ≥95%
  • MDL No. MFCD24113355
  • Storage -20°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula CHF₂NaO₂S
  • Molecular Weight 138.07
  • Synonym(s) Difluoromethanesulfinic acid sodium
  • SMILES O=S(C(F)F)O[Na]

Description

Sodium difluoromethanesulfinate delivers a stable, moisture-tolerant source of the difluoromethylsulfonyl group, enabling direct fluorination in synthetic transformations. This bench-stable reagent integrates efficiently into cross-coupling and electrophilic functionalization protocols, offering precise control over fluorine incorporation with minimal side reactions.

Application

Sodium difluoromethanesulfinate serves as a stable, bench-ready source of the difluoromethylsulfonyl (CF₂SO₂) group, enabling direct fluorination and sulfonation in synthetic workflows. It facilitates efficient incorporation of the CF₂SO₂ moiety into organic substrates under mild conditions, offering high functional group tolerance and compatibility with common reaction setups. Its robustness and ease of handling make it ideal for constructing fluorinated building blocks in medicinal chemistry and materials science applications.

Safety Information

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GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 3261
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H314
Precautionary Statements : P264-P270-P271-P280-P304+P340-P330-P331-P363-P501

Quality Control

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Computational Chemistry Data

  • TPSA   26.3
  • LogP   -0.0272
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

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