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CS-W001157 4
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3-Ethoxypyridin-2-amine

  • CAS No. 10006-74-3

  • Cat. No. CS-0033988
  • Purity≥96%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3-Ethoxypyridin-2-amine|CS-0033988

Structure of 10006-74-3

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General Information

  • CAS No. 10006-74-3
  • Cat. No. CS-0033988
  • Purity ≥96%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₀N₂O
  • Molecular Weight 138.17
  • Synonym(s) 2-Amino-3-ethoxypyridine
  • SMILES NC1=NC=CC=C1OCC

Description

3-Ethoxypyridin-2-amine features a pyridine core functionalized with an ethoxy group at the 3-position and a primary amine at the 2-position. This dual functionality enables direct incorporation into pharmaceutical intermediates, agrochemical scaffolds, and ligands for transition metal catalysis. The molecule exhibits enhanced solubility in organic solvents and stability under standard bench conditions, facilitating straightforward handling in synthetic workflows.

Application

3-Ethoxypyridin-2-amine serves as a versatile building block in medicinal chemistry, enabling the construction of pyridine-based heterocycles via coupling and functionalization reactions. Its ethoxy group enhances solubility and facilitates downstream transformations, while the amino functionality provides a reliable handle for derivatization. The compound exhibits good bench stability and is compatible with standard synthetic protocols, making it suitable for iterative synthesis and process development.

Synthesis

  • Route1

    References

    • BIOGEN IDEC MA INC.; CHAO, Jianhua; ENYEDY, Istvan, J.; GUERTIN, Kevin; HUTCHINGS, Richard, H.; JONES, John, Howard; POWELL, Noel; VANVLOTEN, Kurt, D. Patent: WO2014/8214 A1, 2014 ; Location in patent: Paragraph 00356; 00358 ;
  • Route2

    References

    • WO2014/8214 A1, ;
  • Route3

    References

    • Recueil des Travaux Chimiques des Pays-Bas, , vol. 72, p. 125,131

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

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Computational Chemistry Data

  • TPSA   48.14
  • LogP   1.0625
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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