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CS-W001157 4
Total: USD 88.00

5-Bromo-6-iodo-1H-indole

  • CAS No. 1000343-06-5

  • Cat. No. CS-0131042
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-Bromo-6-iodo-1H-indole|CS-0131042

Structure of 1000343-06-5

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General Information

  • CAS No. 1000343-06-5
  • Cat. No. CS-0131042
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₅BrIN
  • Molecular Weight 321.94
  • Synonym(s) 5-BROMO-6-IODOINDOLE
  • SMILES IC1=CC2=C(C=C1Br)C=CN2

Description

5-Bromo-6-iodo-1H-indole is a halogenated indole scaffold featuring bromine at the 5-position and iodine at the 6-position, enabling diverse cross-coupling transformations. This electron-deficient heterocycle integrates readily into complex molecular architectures, offering enhanced reactivity in palladium-catalyzed processes. Bench-stable and moisture-tolerant, it serves as a strategic building block for pharmaceutical intermediates and functional materials.

Application

5-Bromo-6-iodo-1H-indole serves as a versatile dihalogenated building block for the synthesis of complex heterocyclic scaffolds and pharmaceutical intermediates. Its orthogonal halogen reactivity enables sequential cross-coupling reactions, facilitating efficient access to biaryl and functionalized indole derivatives. The compound exhibits excellent bench stability and is readily purified by standard chromatographic methods, making it well-suited for iterative synthetic workflows in medicinal chemistry and process development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   15.79
  • LogP   3.535
  • H_Acceptors   0
  • H_Donors   1
  • Rotatable_Bonds   0

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