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CS-W001157 4
Total: USD 88.00

4-(Oxazol-2-yl)aniline

  • CAS No. 62882-11-5

  • Cat. No. CS-0103381
  • Purity≥98%
  • MDL No.MFCD11040381

*For research and further manufacturing use only, not for direct human use.

4-(Oxazol-2-yl)aniline|CS-0103381

Structure of 62882-11-5

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General Information

  • CAS No. 62882-11-5
  • Cat. No. CS-0103381
  • Purity ≥98%
  • MDL No. MFCD11040381
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₈N₂O
  • Molecular Weight 160.17
  • Synonym(s) 4-Oxazol-2-yl-phenylaMine
  • SMILES NC1=CC=C(C2=NC=CO2)C=C1

Description

4-(Oxazol-2-yl)aniline features a conjugated oxazole ring directly linked to an aromatic amine, enabling robust integration into heterocyclic scaffolds. This electron-rich arylamine delivers enhanced stability and facilitates direct coupling in transition-metal-catalyzed transformations, offering efficient access to functionalized biaryls under standard conditions.

Application

4-(Oxazol-2-yl)aniline serves as a versatile building block for heterocyclic synthesis, enabling efficient construction of biologically relevant scaffolds. Its compatibility with standard coupling reactions and robust bench stability facilitate straightforward integration into medicinal chemistry workflows. The ortho-oxazole moiety provides enhanced rigidity and polarity, improving solubility and target engagement potential in drug discovery campaigns.

Synthesis

  • Route1
    • 2-(4-Nitrophenyl)oxazole|CS-0204594
      62882-08-0
    • ~88%
    • In-stock
      4-(Oxazol-2-yl)aniline|CS-0103381
      62882-11-5

    References

    • F2G LTD Patent: WO2006/123145 A1, 2006 ; Location in patent: Page/Page column 56 ;
  • Route2
    • Ethyl 2-(4-aminophenyl)oxazole-4-carboxylate|CS-0148194
      391248-21-8
    • ~89%
    • In-stock
      4-(Oxazol-2-yl)aniline|CS-0103381
      62882-11-5

    References

    • Verrier, Cecile; Martin, Thibaut; Hoarau, Christophe; Marsais, Francis Journal of Organic Chemistry, 2008 , vol. 73, # 18 p. 7383 - 7386

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H312-H315-H319-H332-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   52.05
  • LogP   1.9238
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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