Norepinephrine Transporter (NET) Compound Library
| Cat. No. : CS-L906 |
|---|
| （649） |
| Library Contents: |
| On May 15, 2024, "Dimerization and antidepressant recognition at noradrenaline transporter" was published online by Nature. The research findings were an effort from Shanghai Institute of Materia Medica, Chinese Academy of Sciences. This study unraveled the important neural system target - the noradrenaline transporter (NET), obtaining the binding modes of human NET homodimers with the natural substrate norepinephrine (NE) and six selective antidepressants. It laid an important theoretical foundation for understanding the physiological regulation mechanisms of NET and other monoamine transporters. The Norepinephrine Transporter (NET) Compound Library is obtained by computer-aided virtual screening based on the HY-L901 compound library . The specific screening process includes molecular docking screening, key pharmacophore screening, and CNS-MPO screening, which can be used for new drug discovery targeting the noradrenaline transporter. |
| Size (Pre-dissolved DMSO or Solid) | Stock | Price |
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| In-stock | Get quote |
Products are for research use only. Not for human use. We do not sell to patients.
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Data Sheet
Description & Advantages
Composition
| Formulation: | Norepinephrine Transporter (NET) Compound Library is obtained by virtual screening based on HY-L901 50K Diversity Library. It can be applied in new drug discovery targeting noradrenaline transporter (NET). |
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| Container: | 96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode. |
| Storage: | -80°C |
| Shipping: | Blue ice or dry ice |
• A unique collection of 650 small molecules obtained by virtual screening targeting noradrenaline transporter for high throughput screening (HTS) and high content screening (HCS).
• Compatible with “Lipinski” s Rule of Five”, with multiple characteristics such as calculated good permeability (-3.2 • Passed all associated MedChem filters, particularly pan assay interference compound (PAINS) motifs, to remove any inappropriate chemical structures and avoid false hits. • All compounds are available off the shelf. Pre-plates of 10 mM DMSO solutions, convenient to use. • LCMS validated to ensure high purity and quality.
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