Molecular Glue POI binding Fragment library
| Cat. No. : CS-L935 |
|---|
| （1039） |
| Library Contents: |
| POI (Protein of Interest) refers to the target protein, namely the disease-causing protein or key functional protein that undergoes degradation or functional modulation in molecular glue-mediated processes. The Molecular Glue POI Library consists of a series of fragments that can specifically bind to different types of POIs. As key components of molecular glues, these ligands form stable interactions with target proteins, laying the foundation for molecular glues to induce the interaction between POIs and E3 ubiquitin ligases. The covered POIs include various types such as cancer-associated GSPT1, androgen receptors, and abnormally aggregated proteins linked to neurodegenerative diseases. This fragment library can be applied to the screening and optimization of targeted protein degraders. By screening ligands with high affinity and strong selectivity for specific POIs from the library, core structures can be identified to develop novel molecular glues. For instance, optimization of ligands targeting GSPT1 has yielded molecular glue degraders with enhanced degradation activity. Since many POIs are difficult to drug due to the lack of traditional small-molecule binding pockets, some ligands in the POI Ligand Library can modulate such POIs by inducing protein-protein interactions, thereby further expanding the scope of drug discovery for undruggable targets. ChemScene has compiled a POI Fragment Library comprising thousands of POI fragments with molecular weights ranging from 150 to 400. This compound library can be widely applied in Molecular Glue research and development. |
| Size (Pre-dissolved DMSO or Solid) | Stock | Price |
|---|---|---|
| In-stock | Get quote |
Products are for research use only. Not for human use. We do not sell to patients.
Bulk Inquiry
CollapseYour information is safe with us. * Required Fields
Data Sheet
Description & Advantages
Composition
| Formulation: | A compound library can be used for specifically binding to disease-causing target proteins for degradation or modulation as molecular glue fragments. |
|---|---|
| Container: | 96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode. |
| Storage: | -80°C |
| Shipping: | Blue ice or dry ice |
• A unique collection of 1039 compounds can be used for specifically binding to disease-causing target proteins for degradation
• The initial fragments were obtained by the RECAP algorithm from the reported molecular glues, followed by selecting the fragments bound to the POI protein, and finally obtaining a fragment library containing reactive functional groups and POI ligand fragment.
• All compounds are available off the shelf.
• All compounds are validated by LC-MS or NMR to ensure high purity and quality.
Browsing History
| Tags:Molecular Glue POI binding Fragment library supplier, Molecular Glue POI binding Fragment library purchase, Molecular Glue POI binding Fragment library manufacturer, Molecular Glue POI binding Fragment library sigma, Molecular Glue POI binding Fragment library distributor, cost, Molecular Glue POI binding Fragment library buy, Molecular Glue POI binding Fragment library for sale |