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CS-W001157 4
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8-Methyl-8-azabicyclo[3.2.1]octan-3-amine

  • CAS No. 98998-25-5

  • Cat. No. CS-0078597
  • Purity≥96%
  • MDL No.MFCD00210699

*For research and further manufacturing use only, not for direct human use.

8-Methyl-8-azabicyclo[3.2.1]octan-3-amine|CS-0078597

Structure of 98998-25-5

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General Information

  • CAS No. 98998-25-5
  • Cat. No. CS-0078597
  • Purity ≥96%
  • MDL No. MFCD00210699
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₆N₂
  • Molecular Weight 140.23
  • Synonym(s) 8-methyl-8-azabicyclo[3.2.1]octan-3-ylamine
  • SMILES NC1C[C@H]2CC[C@@H](C1)N2C

Description

8-Methyl-8-azabicyclo[3.2.1]octan-3-amine features a rigid, nitrogen-rich bicyclic scaffold that imparts high conformational stability and enhanced basicity. This sterically constrained amine integrates readily into medicinal chemistry libraries, serving as a privileged scaffold for bioactive molecule design.

Application

8-Methyl-8-azabicyclo[3.2.1]octan-3-amine serves as a versatile bicyclic amine scaffold in medicinal chemistry, enabling efficient access to constrained nitrogen-containing heterocycles. Its tertiary amine functionality exhibits favorable basicity and solubility profiles, while the bridged structure imparts conformational rigidity that enhances target binding selectivity. The molecule demonstrates excellent bench stability and compatibility with standard functional group manipulations, facilitating straightforward derivatization for lead optimization campaigns.

Synthesis

  • Route1
    • 8-Methyl-8-azabicyclo[3.2.1]octan-3-one oxime|CS-0756891
      1515-26-0
    • ~76%
    • In-stock
      8-Methyl-8-azabicyclo[3.2.1]octan-3-amine|CS-0078597
      98998-25-5

    References

    • AnorMED, Inc. Patent: US6750348 B1, 2004 ; Location in patent: Page column 111 ; US 6750348 B1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   29.26
  • LogP   0.5703
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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