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1-Methyl-6-oxo-1,6-dihydropyridine-3-carbaldehyde

  • CAS No. 98279-50-6

  • Cat. No. CS-0159765
  • Purity≥97%
  • MDL No.MFCD24674768

*For research and further manufacturing use only, not for direct human use.

1-Methyl-6-oxo-1,6-dihydropyridine-3-carbaldehyde|CS-0159765

Structure of 98279-50-6

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General Information

  • CAS No. 98279-50-6
  • Cat. No. CS-0159765
  • Purity ≥97%
  • MDL No. MFCD24674768
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇NO₂
  • Molecular Weight 137.14
  • Synonym(s) 1-methyl-6-oxopyridine-3-carbaldehyde
  • SMILES O=CC(C=C1)=CN(C)C1=O

Description

1-Methyl-6-oxo-1,6-dihydropyridine-3-carbaldehyde is a bench-stable, electron-deficient dihydropyridine derivative featuring a reactive aldehyde group and a ketone at the 6-position. This bifunctional scaffold integrates readily into heterocyclic syntheses, enabling efficient access to complex nitrogen-containing architectures through one-pot transformations or conjugate additions.

Application

1-Methyl-6-oxo-1,6-dihydropyridine-3-carbaldehyde serves as a versatile scaffold for heterocyclic synthesis, enabling efficient access to pyridine-based pharmacophores. Its conjugated enone-aldehyde system facilitates Michael additions, Mannich reactions, and condensation cascades under mild conditions. Bench-stable and readily purified by flash chromatography, it exhibits broad functional group tolerance, making it well-suited for iterative synthesis in medicinal chemistry and process development workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   39.07
  • LogP   0.1978
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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