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Methyl 6-methoxy-1H-indole-2-carboxylate

  • CAS No. 98081-83-5

  • Cat. No. CS-0067142
  • Purity≥98%
  • MDL No.MFCD00134301
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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*For research and further manufacturing use only, not for direct human use.

Methyl 6-methoxy-1H-indole-2-carboxylate|CS-0067142

Structure of 98081-83-5

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Description

Methyl 6-methoxy-1H-indole-2-carboxylate is a bench-stable, moisture-tolerant indole derivative featuring a methoxy group at the C6 position and a methyl ester at C2. This electron-rich scaffold integrates readily into synthetic sequences requiring polar, conjugated heterocycles.

Application

Methyl 6-methoxy-1H-indole-2-carboxylate serves as a versatile building block for indole-based scaffolds, enabling efficient functionalization at the C2 position. Its methyl ester group facilitates subsequent transformations such as hydrolysis, reduction, or coupling reactions. The 6-methoxy substituent enhances solubility and modulates electronic properties, offering improved stability and handling over unsubstituted analogs. This compound functions reliably in cross-coupling, cyclization, and heterocycle synthesis workflows common in medicinal chemistry and process development.

General Information

  • CAS No. 98081-83-5
  • Cat. No. CS-0067142
  • Purity ≥98%
  • MDL No. MFCD00134301
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₁NO₃
  • Molecular Weight 205.21
  • Synonym(s) Methyl 6-methoxy-2-indolecarboxylate
  • SMILES O=C(C(N1)=CC2=C1C=C(OC)C=C2)OC

Computational Chemistry Data

  • TPSA   51.32
  • LogP   1.9631
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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