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Structure of 97914-59-5
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2-(Difluoromethoxy)benzoic acid features a para-difluoromethoxy substituent that enhances metabolic stability and modulates lipophilicity. This electron-withdrawing group improves membrane permeability while maintaining structural rigidity, making it valuable in medicinal chemistry for optimizing pharmacokinetic profiles. The carboxylic acid moiety enables direct conjugation or derivatization under standard conditions.
2-(Difluoromethoxy)benzoic acid serves as a valuable building block in medicinal chemistry, enabling the introduction of a polar, metabolically stable difluoromethoxy group at the ortho position of a benzoic acid scaffold. Its carboxylic acid functionality facilitates direct coupling reactions, esterifications, and amide formations, while the difluoromethoxy moiety offers enhanced lipophilicity and bioavailability. The compound exhibits good bench stability and is compatible with standard purification methods, making it well-suited for use in API development and high-throughput screening campaigns.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: