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CS-W001157 4
Total: USD 88.00

4-Tritylphenol

  • CAS No. 978-86-9

  • Cat. No. CS-0156532
  • Purity≥98%
  • MDL No.MFCD00002364

*For research and further manufacturing use only, not for direct human use.

4-Tritylphenol|CS-0156532

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General Information

  • CAS No. 978-86-9
  • Cat. No. CS-0156532
  • Purity ≥98%
  • MDL No. MFCD00002364
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₅H₂₀O
  • Molecular Weight 336.43
  • Synonym(s) Phenol, 4-(triphenylmethyl)-
  • SMILES C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=C(C=C4)O

Description

4-Tritylphenol was used in the synthesis of 5-arylethynyl-2-deoxyuridines and propargyl ethers. It may be used in the synthesis of pyridyl rotaxane.

Application

4-Tritylphenol serves as a robust protecting group for phenolic hydroxyls, offering exceptional stability under diverse reaction conditions. Its trityl moiety enables selective deprotection via mild acid treatment, facilitating orthogonal protection strategies in complex molecule synthesis. The compound exhibits excellent bench stability and simplifies purification due to its high molecular weight and low solubility in nonpolar solvents, making it particularly valuable in medicinal chemistry and natural product synthesis workflows.

Synthesis

  • Route1
    • null|null
      162456-86-2
    • ~90%
    • In-stock
      4-Tritylphenol|CS-0156532
      978-86-9

    References

    • Spurg, Anke; Waldvogel, Siegfried R. European Journal of Organic Chemistry, 2008 , # 2 p. 337 - 342
  • Route2
    • Triphenylmethanol Fimasartan Impurity|CS-0228989
      76-84-6
    • null|null
      108-95-2
    • ~92%
    • In-stock
      4-Tritylphenol|CS-0156532
      978-86-9

    References

    • Koshchii, V. A.; Kozlikovskii, Ya. B.; Matyusha, A. A. Journal of Organic Chemistry USSR (English Translation), 1988 , p. 1358 - 1361 Zhurnal Organicheskoi Khimii, 1988 , vol. 24, # 7 p. 1508 - 1512
  • Route3
    • null|null
      139-02-6
    • null|null
      76-83-5
    • ~%
    • In-stock
      4-Tritylphenol|CS-0156532
      978-86-9
    • null|null
      5447-80-3

    References

    • Chemische Berichte, , vol. 60, p. 2254

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   5.7749
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   4

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