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CS-W001157 4
Total: USD 88.00

1,3-Benzothiazole-2,6-diamine

  • CAS No. 5407-51-2

  • Cat. No. CS-0116724
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1,3-Benzothiazole-2,6-diamine|CS-0116724

Structure of 5407-51-2

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General Information

  • CAS No. 5407-51-2
  • Cat. No. CS-0116724
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇N₃S
  • Molecular Weight 165.22
  • Synonym(s) benzothiazole-2,6-diamine
  • SMILES NC1=NC2=CC=C(N)C=C2S1

Description

1,3-Benzothiazole-2,6-diamine features a fused benzene-thiazole core with two strategically positioned primary amine groups. This electron-rich scaffold enables direct integration into functionalized polymers and bioconjugation workflows. The diamine moiety enhances solubility in polar solvents and facilitates metal coordination in catalytic systems. Bench-stable under ambient conditions, it serves as a robust building block for advanced materials and pharmaceutical intermediates.

Application

1,3-Benzothiazole-2,6-diamine serves as a versatile heterocyclic building block for the synthesis of pharmaceutically relevant scaffolds. Its dual amine functionality enables straightforward derivatization via amidation, alkylation, and coupling reactions. The rigid benzothiazole core imparts metabolic stability and favorable binding interactions, making it valuable in medicinal chemistry campaigns targeting kinase inhibitors and CNS agents. Bench-stable and readily purified by recrystallization, it functions effectively in standard peptide and small-molecule synthesis workflows.

Synthesis

  • Route1

    References

    • US2009/233949 A1, ; Page/Page column 10 ;
  • Route2
    • In-stock
      6-Nitrobenzo[d]thiazol-2-amine|CS-W022514
      6285-57-0
    • null|null
      7440-02-0
    • ~49%
    • In-stock
      1,3-Benzothiazole-2,6-diamine|CS-0116724
      5407-51-2

    References

    • US4826860 A1, ;
  • Route3
    • N-(2-Aminobenzo[d]thiazol-6-yl)acetamide|CS-0120103
      22307-44-4
    • ~%
    • In-stock
      1,3-Benzothiazole-2,6-diamine|CS-0116724
      5407-51-2

    References

    • Archiv der Pharmazie (Weinheim, Germany), , p. 31,48

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   64.93
  • LogP   1.4607
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   0

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