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CS-W001157 4
Total: USD 88.00

6-(Trifluoromethoxy)indoline

  • CAS No. 959235-95-1

  • Cat. No. CS-W022436
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

6-(Trifluoromethoxy)indoline|CS-W022436

Structure of 959235-95-1

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General Information

  • CAS No. 959235-95-1
  • Cat. No. CS-W022436
  • Purity ≥95%
  • MDL No. None
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₈F₃NO
  • Molecular Weight 203.16
  • Synonym(s) 1H-Indole,2,3-dihydro-6-(trifluoroMethoxy)-
  • SMILES FC(F)(F)OC1=CC2=C(C=C1)CCN2

Description

6-(Trifluoromethoxy)indoline features a trifluoromethoxy group at the 6-position of the indoline scaffold, conferring enhanced electron-withdrawing character and metabolic stability. This substitution pattern improves solubility in polar solvents and facilitates downstream functionalization in medicinal chemistry applications. The molecule exhibits bench-stable behavior under standard conditions and serves as a key building block for bioactive heterocycles.

Application

6-(Trifluoromethoxy)indoline serves as a versatile building block in medicinal chemistry, enabling direct incorporation of the trifluoromethoxy group into indoline scaffolds. Its bench-stable nature and compatibility with standard coupling reactions facilitate efficient synthesis of functionalized heterocycles. The trifluoromethoxy substituent enhances metabolic stability and modulates lipophilicity, making it valuable for optimizing pharmacokinetic profiles in API development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   21.26
  • LogP   2.5532
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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