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CS-W001157 4
Total: USD 88.00

1-Boc-3-Hydroxypiperidine

  • CAS No. 85275-45-2

  • Cat. No. CS-D0648
  • Purity≥97%
  • MDL No.MFCD02093938

*For research and further manufacturing use only, not for direct human use.

1-Boc-3-Hydroxypiperidine|CS-D0648

Structure of 85275-45-2

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General Information

  • CAS No. 85275-45-2
  • Cat. No. CS-D0648
  • Purity ≥97%
  • MDL No. MFCD02093938
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₉NO₃
  • Molecular Weight 201.26
  • Synonym(s) Tert-Butyl 3-Hydroxy-1-Piperidinecarboxylate; 1-Boc-3-hydroxypiperidine
  • SMILES O=C(OC(C)(C)C)N(CCC1)CC1O

Description

1-Boc-3-Hydroxypiperidine features a protected hydroxyl group and tertiary amine, enabling stable incorporation into complex molecular architectures. This bench-stable derivative simplifies handling in multistep syntheses, serving as a key building block for bioactive piperidine scaffolds in medicinal chemistry.

Application

1-Boc-3-hydroxypiperidine serves as a versatile building block for the synthesis of bioactive piperidine derivatives. The Boc group provides stable protection of the nitrogen, enabling selective functionalization at the 3-hydroxy position. It exhibits excellent bench stability and compatibility with standard coupling and reduction protocols, facilitating efficient access to substituted piperidines used in medicinal chemistry and API development.

Synthesis

  • Route1
    • 3-Hydroxypiperidine|CS-0653435
      6859-99-0
    • In-stock
      Di-tert-butyl dicarbonate|CS-0017817
      24424-99-5
    • ~99%
    • In-stock
      1-Boc-3-Hydroxypiperidine|CS-D0648
      85275-45-2

    References

    • Audouze, Karine; Nielsen, Elsebet stergaard; Olsen, Gunnar M.; Ahring, Philip; Jorgensen, Tino Dyhring; Peters, Dan; Liljefors, Tommy; Balle, Thomas Journal of Medicinal Chemistry, 2006 , vol. 49, # 11 p. 3159 - 3171
  • Route2

    References

    • LG LIFE SCIENCES, LTD. Patent: WO2009/82134 A2, 2009 ; Location in patent: Page/Page column 36-37 ; WO 2009/082134 A2
  • Route3
    • 3-Hydroxypiperidine|CS-0653435
      6859-99-0
    • In-stock
      Di-tert-Butyl carbonate|CS-0146214
      34619-03-9
    • ~85%
    • In-stock
      1-Boc-3-Hydroxypiperidine|CS-D0648
      85275-45-2

    References

    • Sumitomo Pharmaceuticals Company, Limited Patent: EP1403255 A1, 2004 ; Location in patent: Page 93 ; EP 1403255 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   49.77
  • LogP   1.3782
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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