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CS-W001157 4
Total: USD 88.00

6-(Trifluoromethoxy)indoline

  • CAS No. 959235-95-1

  • Cat. No. CS-W022436
  • Purity≥95%
  • MDL No.None
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

6-(Trifluoromethoxy)indoline|CS-W022436

Structure of 959235-95-1

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Description

6-(Trifluoromethoxy)indoline features a trifluoromethoxy group at the 6-position of the indoline scaffold, conferring enhanced electron-withdrawing character and metabolic stability. This substitution pattern improves solubility in polar solvents and facilitates downstream functionalization in medicinal chemistry applications. The molecule exhibits bench-stable behavior under standard conditions and serves as a key building block for bioactive heterocycles.

Application

6-(Trifluoromethoxy)indoline serves as a versatile building block in medicinal chemistry, enabling direct incorporation of the trifluoromethoxy group into indoline scaffolds. Its bench-stable nature and compatibility with standard coupling reactions facilitate efficient synthesis of functionalized heterocycles. The trifluoromethoxy substituent enhances metabolic stability and modulates lipophilicity, making it valuable for optimizing pharmacokinetic profiles in API development.

General Information

  • CAS No. 959235-95-1
  • Cat. No. CS-W022436
  • Purity ≥95%
  • MDL No. None
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₈F₃NO
  • Molecular Weight 203.16
  • Synonym(s) 1H-Indole,2,3-dihydro-6-(trifluoroMethoxy)-
  • SMILES FC(F)(F)OC1=CC2=C(C=C1)CCN2

Computational Chemistry Data

  • TPSA   21.26
  • LogP   2.5532
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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