8-Bromo-6-chloroimidazo[1,2-a]pyridine

Name: 8-Bromo-6-chloroimidazo[1,2-a]pyridine
Brand: ChemScene
Availability: InStock
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CAS No. 957187-27-8
Cat. No. CS-0041819
Purity≥98%
MDL No.MFCD12828062

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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8-Bromo-6-chloroimidazo[1,2-a]pyridine|CS-0041819

Structure of 957187-27-8

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General Information

CAS No. 957187-27-8
Cat. No. CS-0041819
Purity ≥98%
MDL No. MFCD12828062
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₄BrClN₂
Molecular Weight 231.48
Synonym(s) 8-bromo-6-chloroH-imidazo[1,2-a]pyridine
SMILES ClC1=CN2C(C(Br)=C1)=NC=C2

Description

8-Bromo-6-chloroimidazo[1,2-a]pyridine features a fused heterocyclic core with complementary halogen substituents enabling precise functionalization. This electron-deficient scaffold integrates readily into cross-coupling reactions and serves as a key building block for bioactive imidazopyridine derivatives in medicinal chemistry and materials science.

Application

8-Bromo-6-chloroimidazo[1,2-a]pyridine serves as a versatile building block for constructing substituted imidazopyridine scaffolds prevalent in medicinal chemistry. The molecule features orthogonal halogen handles—bromine at C8 and chlorine at C6—that enable sequential palladium-catalyzed cross-coupling reactions. Its stability under standard reaction conditions facilitates purification and integration into complex heterocyclic architectures, making it well-suited for the synthesis of kinase inhibitors and other bioactive compounds.

Synthesis

Route1
- 107-20-0
- In-stock
  
  26163-03-1
- ~89%
- In-stock
  
  957187-27-8
References
- GENENTECH, INC.; Crawford, James John; Ortwine, Daniel Fred; Young, Wendy B. Patent: US2013/116262 A1, 2013 ; Location in patent: Paragraph 0195; 0196; 0197 ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 17.3
LogP 2.7502
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Imidazole compounds

Key Words

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8-Bromo-6-chloroimidazo[1,2-a]pyridine

CAS No. 957187-27-8

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