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CS-W001157 4
Total: USD 88.00

2-Fluoro-4-methanesulfonylphenylboronic acid

  • CAS No. 957060-85-4

  • Cat. No. CS-0040119
  • Purity≥98%
  • MDL No.MFCD09027248

*For research and further manufacturing use only, not for direct human use.

2-Fluoro-4-methanesulfonylphenylboronic acid|CS-0040119

Structure of 957060-85-4

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General Information

  • CAS No. 957060-85-4
  • Cat. No. CS-0040119
  • Purity ≥98%
  • MDL No. MFCD09027248
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₈BFO₄S
  • Molecular Weight 218.01
  • Synonym(s) 2-Fluoro-4-(methylsulfonyl)phenylboronic acid
  • SMILES O=S(C1=CC=C(B(O)O)C(F)=C1)(C)=O

Description

2-Fluoro-4-methanesulfonylphenylboronic acid features a boronic acid group flanked by electron-withdrawing fluorine and methanesulfonyl substituents, enhancing its stability and reactivity in Suzuki-Miyaura coupling. This combination enables efficient cross-coupling under mild conditions, delivering arylated products with high fidelity. The molecule exhibits bench-stable handling and compatibility with diverse reaction matrices, making it ideal for complex molecular assembly in synthetic and medicinal chemistry workflows.

Application

2-Fluoro-4-methanesulfonylphenylboronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient C–C bond formation under mild conditions. The fluorine and methanesulfonyl groups provide orthogonal reactivity and enhanced stability, facilitating selective transformations and simplifying purification. Its bench-stable nature and compatibility with diverse functional groups make it well-suited for the synthesis of complex aryl scaffolds in medicinal chemistry and materials science applications.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   74.6
  • LogP   -1.091
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   2

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