3-Fluoro-4-(methylsulfonyl)phenylboronic acid

Name: 3-Fluoro-4-(methylsulfonyl)phenylboronic acid
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 648904-83-0
Cat. No. CS-0130373
Molecule weight218.01
Purity≥97%
MDL No.None

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

3-Fluoro-4-(methylsulfonyl)phenylboronic acid|CS-0130373

Structure of 648904-83-0

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 648904-83-0
Cat. No. CS-0130373
Purity ≥97%
MDL No. None
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₈BFO₄S
Molecular Weight 218.01
Synonym(s) None
SMILES OB(O)C1=CC=C(C(F)=C1)S(=O)(C)=O

Description

3-Fluoro-4-(methylsulfonyl)phenylboronic acid features a boronate moiety paired with electron-withdrawing fluorine and methylsulfonyl groups, enhancing stability and enabling selective cross-coupling in Suzuki-Miyaura reactions. This bench-stable reagent integrates readily into complex molecule synthesis under standard conditions.

Application

3-Fluoro-4-(methylsulfonyl)phenylboronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient C–C bond formation under mild conditions. The ortho-fluoro substituent enhances regioselectivity and metabolic stability, while the methylsulfonyl group provides excellent solubility and functional group tolerance. Bench-stable and readily purified by recrystallization, it facilitates the synthesis of substituted biaryls and heterocyclic scaffolds relevant to medicinal chemistry and materials science.

Synthesis

Route1
- In-stock
  
  648904-85-2
- ~42%
- In-stock
  
  648904-83-0
References
- ELI LILLY AND COMPANY Patent: WO2004/9086 A1, 2004 ; Location in patent: Page/Page column 22-23 ; WO 2004/009086 A1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 74.6
LogP -1.091
H_Acceptors 4
H_Donors 2
Rotatable_Bonds 2

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Functional Group Boronic Acid And Its Ester

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

648904-83-0 sigma648904-83-0 manufacturer648904-83-0 price648904-83-0 structure648904-83-0 SDSbuy 648904-83-0648904-83-0 supplier648904-83-0 uses648904-83-0 molecular weightprice of 648904-83-0648904-83-0 chemical name formula of 648904-83-0

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

3-Fluoro-4-(methylsulfonyl)phenylboronic acid

CAS No. 648904-83-0

Recommended Products