6-Chloro-2-methoxynicotinaldehyde

Name: 6-Chloro-2-methoxynicotinaldehyde
Brand: ChemScene
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CAS No. 95652-81-6
Cat. No. CS-0037312
Purity≥95%
MDL No.MFCD11847276

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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6-Chloro-2-methoxynicotinaldehyde|CS-0037312

Structure of 95652-81-6

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Description

6-Chloro-2-methoxynicotinaldehyde features a chlorine substituent at the 6-position and a methoxy group at the 2-position, creating a highly electron-deficient pyridine core. This configuration enhances reactivity in nucleophilic addition and coupling processes, particularly in the synthesis of heterocyclic scaffolds and bioactive molecules. The aldehyde functionality enables direct integration into complex architectures under mild conditions.

Application

6-Chloro-2-methoxynicotinaldehyde serves as a versatile building block in medicinal chemistry, enabling the synthesis of substituted pyridine scaffolds via standard coupling reactions. Its orthogonal functional groups—chlorine at C6 and methoxy at C2—facilitate selective transformations, while the aldehyde functionality supports reductive amination, imine formation, and Ugi-type condensations. The compound exhibits good bench stability and is amenable to purification by column chromatography or distillation, supporting its use in multi-step syntheses.

General Information

CAS No. 95652-81-6
Cat. No. CS-0037312
Purity ≥95%
MDL No. MFCD11847276
Storage 4°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₆ClNO₂
Molecular Weight 171.58
Synonym(s) 6-CHLORO-2-METHOXY-3-PYRIDINECARBALDEHYDE
SMILES COC1=C(C=CC(=N1)Cl)C=O

Computational Chemistry Data

TPSA 39.19
LogP 1.5561
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 2

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H317-H319-H335
Precautionary Statements : P261-P264-P270-P271-P272-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Other Classifications

Building Blocks Functional Group Aldehyde

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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6-Chloro-2-methoxynicotinaldehyde

CAS No. 95652-81-6

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