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CS-W001157 4
Total: USD 88.00

3-Methoxy-2,6-dimethyl-aniline

  • CAS No. 95645-00-4

  • Cat. No. CS-0310184
  • Purity≥96%
  • MDL No.MFCD08693118

*For research and further manufacturing use only, not for direct human use.

3-Methoxy-2,6-dimethyl-aniline|CS-0310184

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General Information

  • CAS No. 95645-00-4
  • Cat. No. CS-0310184
  • Purity ≥96%
  • MDL No. MFCD08693118
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₃NO
  • Molecular Weight None
  • Synonym(s) None
  • SMILES COC1C(C)=C(N)C(C)=CC=1

Description

3-Methoxy-2,6-dimethyl-aniline features a methoxy group flanked by two methyl substituents on the aromatic ring, enhancing electron density at the para-position. This configuration improves solubility in organic solvents and stabilizes reactive intermediates in coupling reactions. The molecule serves as a selective building block for functionalized anilines in pharmaceutical synthesis and dye development.

Application

3-Methoxy-2,6-dimethyl-aniline serves as a valuable building block in medicinal chemistry and agrochemical synthesis, offering a sterically hindered aromatic amine with enhanced solubility and stability. Its ortho-methyl groups provide steric protection, while the methoxy substituent offers moderate electron donation, facilitating controlled electrophilic substitution and coupling reactions. The compound functions reliably in Suzuki-Miyaura, Ullmann, and Buchwald-Hartwig couplings, enabling efficient access to complex heterocyclic scaffolds and functionalized aryl derivatives under standard reaction conditions.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H312-H315-H319-H332-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

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Computational Chemistry Data

  • TPSA   35.25
  • LogP   1.89424
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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