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CS-W001157 4
Total: USD 88.00

4-(Vinylsulfonyl)benzoic acid

  • CAS No. 95535-40-3

  • Cat. No. CS-W022035
  • Molecule weight212.22
  • Purity≥95%
  • MDL No.MFCD11519203

*For research and further manufacturing use only, not for direct human use.

4-(Vinylsulfonyl)benzoic acid|CS-W022035

Structure of 95535-40-3

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General Information

  • CAS No. 95535-40-3
  • Cat. No. CS-W022035
  • Purity ≥95%
  • MDL No. MFCD11519203
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₈O₄S
  • Molecular Weight 212.22
  • Synonym(s) 4-(ethenylsulfonyl)benzoic acid
  • SMILES O=C(O)C1=CC=C(S(=O)(C=C)=O)C=C1

Description

4-(Vinylsulfonyl)benzoic acid features a reactive vinylsulfonyl group paired with a carboxylic acid functionality, enabling dual conjugation pathways. This bifunctional architecture supports efficient coupling in bioconjugation and polymer functionalization under mild conditions. The molecule exhibits high stability and solubility in aqueous and organic media, facilitating use in diverse synthetic workflows.

Application

4-(Vinylsulfonyl)benzoic acid serves as a versatile bifunctional building block for conjugate additions and Michael reactions, enabling efficient incorporation of vinylsulfone moieties into complex architectures. The pendant vinyl group exhibits high reactivity toward nucleophiles, while the carboxylic acid facilitates derivatization via standard coupling protocols. Its bench-stable nature and compatibility with diverse functional groups make it a practical choice for synthesizing bioconjugates and targeted therapeutics.

Synthesis

  • Route1
    • null|null
      17918-95-5
    • ~83%
    • 4-(Vinylsulfonyl)benzoic acid|CS-W022035
      95535-40-3

    References

    • Horner, Leopold; Lindel, Hans Liebigs Annalen der Chemie, 1985 , # 1 p. 22 - 33
  • Route2
    • null|null
      7185-00-4
    • ~%
    • 4-(Vinylsulfonyl)benzoic acid|CS-W022035
      95535-40-3

    References

    • Liebigs Annalen der Chemie, , # 1 p. 22 - 33

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   71.44
  • LogP   1.302
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   3

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