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CS-W001157 4
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4-(6-Bromopyridin-3-yl)morpholine

  • CAS No. 952582-08-0

  • Cat. No. CS-0036637
  • Molecule weight243.10
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-(6-Bromopyridin-3-yl)morpholine|CS-0036637

Structure of 952582-08-0

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General Information

  • CAS No. 952582-08-0
  • Cat. No. CS-0036637
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₁BrN₂O
  • Molecular Weight 243.10
  • Synonym(s) 4-(6-Bromopyridin-3-yl)
  • SMILES C1=CC(=NC=C1N2CCOCC2)Br

Description

4-(6-Bromopyridin-3-yl)morpholine features a brominated pyridine moiety linked to a morpholine ring, delivering a versatile scaffold for medicinal chemistry. The electron-rich morpholine enhances solubility and metabolic stability, while the bromine serves as a pivotal handle for palladium-catalyzed cross-coupling reactions. This compound integrates seamlessly into diverse synthetic pathways requiring targeted functionalization.

Application

4-(6-Bromopyridin-3-yl)morpholine serves as a versatile building block for palladium-catalyzed cross-coupling reactions, enabling efficient construction of biaryl and heteroaryl scaffolds. The bromopyridine moiety provides high reactivity in Suzuki, Stille, and Negishi couplings, while the morpholine ring offers favorable solubility and metabolic stability. Bench-stable and readily purified by flash chromatography, it functions reliably in medicinal chemistry campaigns and process development workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   25.36
  • LogP   1.6807
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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