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CS-W001157 4
Total: USD 88.00

3-Bromo-1H-pyrazol-5-amine

  • CAS No. 950739-21-6

  • Cat. No. CS-B0747
  • Purity≥97%
  • MDL No.MFCD18801156

*For research and further manufacturing use only, not for direct human use.

3-Bromo-1H-pyrazol-5-amine|CS-B0747

Structure of 950739-21-6

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General Information

  • CAS No. 950739-21-6
  • Cat. No. CS-B0747
  • Purity ≥97%
  • MDL No. MFCD18801156
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃H₄BrN₃
  • Molecular Weight 161.99
  • Synonym(s) 3-bromo-5-aminopyrazole
  • SMILES NC1=CC(Br)=NN1

Description

3-Bromo-1H-pyrazol-5-amine features a bromine substituent at the 3-position and an amine group at the 5-position of the pyrazole ring, enabling direct functionalization in heterocyclic synthesis. This electron-deficient scaffold integrates readily into bioactive molecule design, offering high reactivity in palladium-catalyzed coupling reactions. The compound exhibits bench-stable handling under standard conditions and serves as a key intermediate in medicinal chemistry and materials science applications.

Application

3-Bromo-1H-pyrazol-5-amine serves as a versatile building block for heterocyclic synthesis, enabling palladium-catalyzed cross-coupling reactions to construct biologically relevant pyrazole derivatives. The bromo group facilitates efficient Suzuki, Stille, and Negishi couplings, while the primary amine offers direct functionalization potential. Its bench-stable crystalline form simplifies handling and purification, making it well-suited for medicinal chemistry campaigns and API intermediate development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H320-H335
Precautionary Statements : P261-P280-P302+P352

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Computational Chemistry Data

  • TPSA   54.7
  • LogP   0.7544
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   0

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