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CS-W001157 4
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7-Bromo-5-fluoro-2,3-dihydro-1H-indol-2-one

  • CAS No. 945379-34-0

  • Cat. No. CS-0050070
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

7-Bromo-5-fluoro-2,3-dihydro-1H-indol-2-one|CS-0050070

Structure of 945379-34-0

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General Information

  • CAS No. 945379-34-0
  • Cat. No. CS-0050070
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₅BrFNO
  • Molecular Weight 230.03
  • Synonym(s) 7-bromo-5-fluoro-1,3-dihydro-indol-2-one
  • SMILES FC1=CC2=C(NC(=O)C2)C(Br)=C1

Description

7-Bromo-5-fluoro-2,3-dihydro-1H-indol-2-one features a sterically hindered indolinone core with complementary halogen substituents at the 7- and 5-positions. This electron-deficient scaffold integrates readily into C–H functionalization cascades and serves as a key building block for bioactive heterocycles in medicinal chemistry.

Application

7-Bromo-5-fluoro-2,3-dihydro-1H-indol-2-one serves as a versatile building block for the synthesis of biologically active indole scaffolds. Its bromo and fluoro substituents enable selective cross-coupling reactions and facilitate downstream functionalization. The dihydroindolone core provides structural rigidity and favorable reactivity in palladium-catalyzed transformations, making it well-suited for medicinal chemistry applications requiring precise substitution patterns and metabolic stability.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   29.1
  • LogP   2.0828
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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