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7-Methyl-2H-indazole-3-carbaldehyde

  • CAS No. 1000340-51-1

  • Cat. No. CS-0439507
  • Purity≥97%
  • MDL No.MFCD09027036

*For research and further manufacturing use only, not for direct human use.

7-Methyl-2H-indazole-3-carbaldehyde|CS-0439507

Structure of 1000340-51-1

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General Information

  • CAS No. 1000340-51-1
  • Cat. No. CS-0439507
  • Purity ≥97%
  • MDL No. MFCD09027036
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₈N₂O
  • Molecular Weight 160.17
  • Synonym(s) 7-methyl-1H-indazole-3-carbaldehyde
  • SMILES CC1=CC=CC2=C(C=O)NN=C12

Description

7-Methyl-2H-indazole-3-carbaldehyde features a fused bicyclic indazole core with a methyl group at the 7-position and an aldehyde handle at the 3-position. This combination delivers a sterically accessible, electron-deficient carbonyl site ideal for nucleophilic addition and coupling reactions in medicinal chemistry. The bench-stable aldehyde integrates readily into diverse heterocyclic scaffolds under mild conditions.

Application

7-Methyl-2H-indazole-3-carbaldehyde serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the aldehyde position for Suzuki-Miyaura coupling, reductive amination, or imine formation. The indazole core provides enhanced metabolic stability and favorable binding interactions in kinase inhibitors and CNS-targeted therapeutics. Bench-stable and readily purified by flash chromatography, it functions efficiently in standard synthetic workflows requiring orthogonally protected heterocycles.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   45.75
  • LogP   1.68382
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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