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Ethyl 6-bromoimidazo[1,2-a]pyrimidine-2-carboxylate

  • CAS No. 944896-67-7

  • Cat. No. CS-0047129
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Ethyl 6-bromoimidazo[1,2-a]pyrimidine-2-carboxylate|CS-0047129

Structure of 944896-67-7

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General Information

  • CAS No. 944896-67-7
  • Cat. No. CS-0047129
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₈BrN₃O₂
  • Molecular Weight 270.08
  • Synonym(s) ETHYL 6-BROMOIMIDAZO[1,2-A]PYRIMIDINE-2-CARBOXYLIC ACID
  • SMILES O=C(C1=CN2C(N=CC(Br)=C2)=N1)OCC

Description

Ethyl 6-bromoimidazo[1,2-a]pyrimidine-2-carboxylate features a brominated imidazopyrimidine core that enables direct functionalization in cross-coupling reactions. The ester group enhances solubility and facilitates downstream derivatization. This bench-stable, moisture-tolerant building block integrates readily into heterocyclic scaffolds for medicinal chemistry applications.

Application

Ethyl 6-bromoimidazo[1,2-a]pyrimidine-2-carboxylate serves as a versatile building block for the synthesis of imidazopyrimidine-based scaffolds. The bromine at the C6 position enables palladium-catalyzed cross-coupling reactions, while the ester group facilitates further derivatization. Its bench-stable nature and compatibility with standard synthetic protocols make it well-suited for medicinal chemistry campaigns targeting kinase inhibitors and other bioactive heterocycles.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   56.49
  • LogP   1.6685
  • H_Acceptors   5
  • H_Donors   0
  • Rotatable_Bonds   2

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