Lot numbers can be found on the outside label of a product:
5-Bromo-4-fluoro-2-pyridinamine
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CAS No. 944401-69-8
- Cat. No. CS-W019689
- Purity≥98%
- MDL No.MFCD16658678
*For research and further manufacturing use only, not for direct human use.
Structure of 944401-69-8
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General Information
- CAS No. 944401-69-8
- Cat. No. CS-W019689
- Purity ≥98%
- MDL No. MFCD16658678
- Storage 4°C, protect from light
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₅H₄BrFN₂
- Molecular Weight 191.00
- Synonym(s) 2-Amino-4-fluoro-5-bromopyridine; 2-Amino-5-bromo-4-fluoropyridine; 5-Bromo-4-fluoropyridin-2-amine; 5-bromo-4-fluoro-pyridin-2-amine
- SMILES NC1=NC=C(Br)C(F)=C1
Description
5-Bromo-4-fluoro-2-pyridinamine features a halogenated pyridine core with strategically positioned bromo and fluoro substituents, enabling selective coupling reactions. This bench-stable derivative integrates readily into medicinal chemistry scaffolds, offering enhanced reactivity in cross-coupling and bioconjugation workflows.
Application
5-Bromo-4-fluoro-2-pyridinamine serves as a versatile building block for the synthesis of heterocyclic compounds and pharmaceutical intermediates. Its ortho-halogenated pyridine core enables palladium-catalyzed cross-coupling reactions, while the amino group facilitates further functionalization. The molecule exhibits good bench stability and compatibility with standard reaction conditions, enabling efficient access to complex scaffolds in medicinal chemistry and process development workflows.
Synthesis
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Route1
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In-stock
944401-77-8 - ~65%
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In-stock
944401-69-8
References
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NOVARTIS AG Patent: WO2007/84786 A1, 2007 ; Location in patent: Page/Page column 108 ; WO 2007/084786 A1
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Route2
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944402-15-7 - ~65%
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In-stock
944401-69-8
References
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NOVARTIS AG Patent: WO2007/84786 A1, 2007 ; Location in patent: Page/Page column 102 ; WO 2007/084786 A1
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Route3
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In-stock
34941-91-8 - ~%
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In-stock
944401-69-8
References
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UCB PHARMA S.A.; BENTLEY, Jonathan Mark; BROOKINGS, Daniel Christopher; BROWN, Julien Alistair; CAIN, Thomas Paul; CHOVATIA, Praful Tulshi; FOLEY, Anne Marie; GALLIMORE, Ellen Olivia; GLEAVE, Laura Jane; HEIFETZ, Alexander; HORSLEY, Helen Tracey; HUTCHINGS, Martin Clive; JACKSON, Victoria Elizabeth; JOHNSON, James Andrew; JOHNSTONE, Craig; KROEPLIEN, Boris; LECOMTE, Fabien Claude; LEIGH, Deborah; LOWE, Martin Alexander; MADDEN, James; PORTER, John Robert; QUINCEY, Joanna Rachel; REED, Laura Claire; REUBERSON, James Thomas; RICHARDSON, Anthony John; RICHARDSON, Sarah Emily; SELBY, Matthew Duncan; SHAW, Michael Alan; ZHU, Zhaoning Patent: WO2014/9295 A1, 2014 ;
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 38.91
- LogP 1.5654
- H_Acceptors 2
- H_Donors 1
- Rotatable_Bonds 0
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Key Words
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