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Propargyl-PEG2-MS

  • CAS No. 943726-01-0

  • Cat. No. CS-0109259
  • Purity≥95%
  • MDL No.MFCD29042346

*For research and further manufacturing use only, not for direct human use.

Propargyl-PEG2-MS|CS-0109259

Structure of 943726-01-0

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General Information

  • CAS No. 943726-01-0
  • Cat. No. CS-0109259
  • Purity ≥95%
  • MDL No. MFCD29042346
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₄O₅S
  • Molecular Weight 222.26
  • Synonym(s) None
  • SMILES C#CCOCCOCCOS(C)(=O)=O

Description

Propargyl-PEG2-MS features a reactive maleimide group flanked by a short PEG spacer and a terminal alkyne, enabling site-specific bioconjugation via copper-catalyzed azide-alkyne cycloaddition or strain-promoted variants. This bifunctional linker combines aqueous solubility with orthogonal reactivity, streamlining the integration of biomolecules into functionalized surfaces or delivery systems.

Application

Propargyl-PEG2-MS serves as a versatile bifunctional linker for bioconjugation and polymer chemistry. The propargyl group enables reliable copper-catalyzed azide-alkyne cycloaddition (CuAAC), while the maleimide moiety selectively reacts with thiols under physiological conditions. This combination facilitates efficient, site-specific conjugation in peptide, protein, and oligonucleotide modifications, with PEG2 providing enhanced solubility and reduced non-specific binding.

Safety Information

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GHS Pictogram : N/A
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Hazard Statements : N/A
Precautionary Statements : N/A

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Computational Chemistry Data

  • TPSA   61.83
  • LogP   -0.371
  • H_Acceptors   5
  • H_Donors   0
  • Rotatable_Bonds   8

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