tert-Butyl thiazol-5-ylcarbamate

Name: tert-Butyl thiazol-5-ylcarbamate
Brand: ChemScene
Availability: InStock
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CAS No. 942631-50-7
Cat. No. CS-0146845
Purity≥95%
MDL No.MFCD11977627

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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tert-Butyl thiazol-5-ylcarbamate|CS-0146845

Structure of 942631-50-7

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General Information

CAS No. 942631-50-7
Cat. No. CS-0146845
Purity ≥95%
MDL No. MFCD11977627
Storage 4°C, protect from light, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₁₂N₂O₂S
Molecular Weight 200.26
Synonym(s) 5-(Boc-amino)thiazole
SMILES O=C(OC(C)(C)C)NC1=CN=CS1

Description

tert-Butyl thiazol-5-ylcarbamate features a robust tert-butyl carbamate protecting group attached to a thiazole heterocycle, enabling stable incorporation of nitrogen functionalities in synthetic sequences. This bench-stable reagent facilitates efficient coupling and deprotection workflows under standard conditions, particularly valuable in medicinal chemistry and peptide conjugation strategies where controlled nitrogen delivery is essential.

Application

tert-Butyl thiazol-5-ylcarbamate serves as a robust, bench-stable building block for the synthesis of thiazole-containing pharmaceuticals and agrochemicals. Its carbamate group enables selective protection of primary amines under mild conditions, facilitating orthogonal functionalization in complex molecule assembly. The thiazol-5-yl moiety participates reliably in palladium-catalyzed cross-coupling reactions, offering direct access to biologically relevant heterocyclic scaffolds with high functional group tolerance and ease of purification.

Synthesis

Route1
- In-stock
  
  14527-41-4
- 75-65-0
- ~42%
- In-stock
  
  942631-50-7
References
- ABBOTT GMBH and CO. KG; ABBVIE INC.; GENESTE, Hervé; OCHSE, Michael; DRESCHER, Karla; JAKOB, Clarissa; TORRENT, Maricel; YAO, Shanshan; ZHAO, Xiaoling; WANG, Liang Patent: WO2014/41175 A1, 2014 ; Location in patent: Page/Page column 54-55 ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 51.22
LogP 2.4901
H_Acceptors 4
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Amine

Building Blocks Skeleton Aromatic heterocycle compounds Thiazole compounds

Key Words

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tert-Butyl thiazol-5-ylcarbamate

CAS No. 942631-50-7

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