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CS-W001157 4
Total: USD 88.00

4-Bromo-7-fluorobenzo[d]thiazol-2-amine

  • CAS No. 942473-89-4

  • Cat. No. CS-0119368
  • Purity≥97%
  • MDL No.MFCD09475480

*For research and further manufacturing use only, not for direct human use.

4-Bromo-7-fluorobenzo[d]thiazol-2-amine|CS-0119368

Structure of 942473-89-4

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General Information

  • CAS No. 942473-89-4
  • Cat. No. CS-0119368
  • Purity ≥97%
  • MDL No. MFCD09475480
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₄BrFN₂S
  • Molecular Weight 247.09
  • Synonym(s) 4-bromo-7-fluoro-1,3-benzothiazol-2-amine
  • SMILES NC1=NC2=C(Br)C=CC(F)=C2S1

Description

4-Bromo-7-fluorobenzo[d]thiazol-2-amine features a fused benzothiazole core with complementary halogen substituents enabling diverse cross-coupling transformations. The electron-deficient aryl ring pairs with the amine handle to support efficient palladium-catalyzed functionalization, while the bromo and fluoro groups offer orthogonal reactivity for sequential derivatization. This scaffold delivers robust performance in synthetic medicinal chemistry workflows.

Application

4-Bromo-7-fluorobenzo[d]thiazol-2-amine serves as a versatile building block for constructing bioactive heterocycles, enabling palladium-catalyzed cross-coupling reactions with high functional group tolerance. The bromo and fluoro substituents provide orthogonal reactivity for sequential derivatization, while the thiazole amine facilitates direct incorporation into pharmaceutical scaffolds. Its bench-stable crystalline form simplifies handling and purification in multi-step syntheses.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   2.7801
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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