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CS-W001157 4
Total: USD 88.00

1-Phenylpiperidine-4-carboxylic acid

  • CAS No. 94201-40-8

  • Cat. No. CS-W019343
  • Molecule weight205.25
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-Phenylpiperidine-4-carboxylic acid|CS-W019343

Structure of 94201-40-8

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General Information

  • CAS No. 94201-40-8
  • Cat. No. CS-W019343
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₅NO₂
  • Molecular Weight 205.25
  • Synonym(s) None
  • SMILES OC(=O)C1CCN(CC1)C1=CC=CC=C1

Description

1-Phenylpiperidine-4-carboxylic acid features a rigid piperidine core bearing a phenyl group and a carboxylic acid at the 4-position, enabling strong hydrogen bonding and defined spatial orientation. This scaffold delivers high metabolic stability and favorable solubility profiles, making it ideal for medicinal chemistry campaigns targeting CNS disorders and receptor modulators.

Application

1-Phenylpiperidine-4-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and pharmaceutical scaffolds. Its carboxylic acid functionality facilitates direct coupling reactions, while the piperidine core provides favorable physicochemical properties for drug-like molecules. The compound exhibits good bench stability and compatibility with standard peptide coupling protocols, supporting efficient derivatization and purification in multi-step syntheses.

Synthesis

  • Route1

    References

    • Calvo, Raul R.; Cheung, Wing S.; Player, Mark R. Patent: US2006/116368 A1, 2006 ; Location in patent: Page/Page column 56; 57 ;
  • Route2
    • Ethyl 1-phenylpiperidine-4-carboxylate|CS-0323887
      247022-37-3
    • ~%
    • In-stock
      1-Phenylpiperidine-4-carboxylic acid|CS-W019343
      94201-40-8

    References

    • Merck and Co., Inc. Patent: US5891889 A1, 1999 ; US 5891889 A
  • Route3
    • null|null
      857806-58-7
    • ~%
    • In-stock
      1-Phenylpiperidine-4-carboxylic acid|CS-W019343
      94201-40-8

    References

    • Prelog; Hanousek Collection of Czechoslovak Chemical Communications, 1934 , vol. 6, p. 225,226, 230

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301
Precautionary Statements : P264-P270-P330-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   40.54
  • LogP   1.9876
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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