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CS-W001157 4
Total: USD 88.00

1,3-Dichloro-5-fluoro-2-iodobenzene

  • CAS No. 939990-10-0

  • Cat. No. CS-0060182
  • Molecule weight290.89
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1,3-Dichloro-5-fluoro-2-iodobenzene|CS-0060182

Structure of 939990-10-0

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General Information

  • CAS No. 939990-10-0
  • Cat. No. CS-0060182
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₂Cl₂FI
  • Molecular Weight 290.89
  • Synonym(s) 2,6-Dichloro-4-fluoroiodobenzene
  • SMILES C1=C(C=C(C(=C1Cl)I)Cl)F

Description

1,3-Dichloro-5-fluoro-2-iodobenzene features a highly functionalized aromatic core with orthogonal halogens enabling sequential cross-coupling. The strategic placement of chlorine, fluorine, and iodine facilitates selective transformations in palladium-catalyzed reactions. This electron-deficient benzene derivative offers enhanced reactivity and stability under standard conditions, making it ideal for complex molecular assembly in medicinal chemistry and materials science.

Application

1,3-Dichloro-5-fluoro-2-iodobenzene serves as a versatile aryl building block for palladium-catalyzed cross-coupling reactions. Its orthogonal halogen reactivity enables sequential functionalization, while the fluorine and chlorine substituents enhance metabolic stability and modulate electronic properties. The compound exhibits excellent bench stability and facilitates straightforward purification, making it well-suited for iterative synthesis of complex heterocycles and pharmaceutical intermediates.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   0
  • LogP   3.7371
  • H_Acceptors   0
  • H_Donors   0
  • Rotatable_Bonds   0

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