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CS-W001157 4
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Benzyl 3-iodoazetidine-1-carboxylate

  • CAS No. 939759-26-9

  • Cat. No. CS-0045527
  • Purity≥95%
  • MDL No.MFCD09026510
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Benzyl 3-iodoazetidine-1-carboxylate|CS-0045527

Structure of 939759-26-9

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Description

Benzyl 3-iodoazetidine-1-carboxylate is a sterically constrained, bench-stable heterocyclic building block featuring a reactive iodide at the 3-position of the azetidine ring. This electrophilic handle enables efficient late-stage functionalization via cross-coupling reactions, facilitating rapid access to diverse nitrogen-containing scaffolds in medicinal chemistry and chemical biology applications.

Application

Benzyl 3-iodoazetidine-1-carboxylate serves as a versatile building block in synthetic organic chemistry, enabling efficient access to azetidine-containing scaffolds via palladium-catalyzed cross-coupling reactions. The iodide group facilitates reliable functionalization under standard coupling conditions, while the benzyl ester offers convenient deprotection and stability under routine reaction protocols. Its compact strained ring system enhances reactivity in cyclization and fragment coupling processes, making it valuable for medicinal chemistry and process development workflows.

General Information

  • CAS No. 939759-26-9
  • Cat. No. CS-0045527
  • Purity ≥95%
  • MDL No. MFCD09026510
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₂INO₂
  • Molecular Weight 317.12
  • Synonym(s) 1-Cbz-3-iodo-azetidine
  • SMILES IC1CN(C1)C(=O)OCC1=CC=CC=C1

Computational Chemistry Data

  • TPSA   29.54
  • LogP   2.4424
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

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